Pharmaceutical chemistry I.

Lecture:

Curse code: GYTKKAM231

Type of subject: compulsory

Credit value: 4

Number of contact hours (per week): 4

Form of mid-year report: -

Assessment/examination form: colloquium

Site in curriculum: Semester 5

Subject prerequisite(s): Quantitative Chemical Analysis lecture (GYTKKAM101), Organic Chemistry 2. (GYTKKAM123), Pharmaceutical Chemistry 1. practice (GYTKKAM232)

Head of subject: Dr. László Lázár

Instructors involved in subject teaching: Dr. Márta Palkó, Prof. Dr. Zsolt Szakonyi, Dr. Zita Zalán

Lecture:

Curse code: GYTKKAM233

Type of subject: compulsory

Credit value: 5

Number of contact hours (per week): 4

Form of mid-year report: -

Assessment/examination form: final exam

Site in curriculum: Semester 6

Subject prerequisite(s): Pharmaceutical Chemistry 1. lecture (GYTKKAM231), Pharmaceutical Chemistry 1. practice (GYTKKAM232)

Head of subject: Prof. Dr. Zsolt Szakonyi

Instructors involved in subject teaching: Dr. László Lázár, Dr. Márta Palkó, Dr. Zita Zalán

The aim of the lectures in pharmaceutical chemistry is to give students an insight into the inorganic and organic drug molecules found in the pharmaceutical practice, and to understand their physical and chemical properties and biological effects. Particular emphasis will be placed on the chemical properties, reactions and attitudes underlying the pharmacological action of the drug compounds, and overview of molecular interactions, a combination of the pharmaceutical approach and the chemical thinking. The lectures present the most important representatives of each class of drug compounds, their structure-activity relationships, in some cases including their specific pharmacopoeial identity and / or purity assays and typical methods of their syntheses.

Practice:

Curse code: GYTKKAM234

Type of subject: compulsory

Credit value: 5

Number of contact hours (per week): 6

Form of mid-year report: written MTO (2 times), short test (4-8 times)

Assessment/examination form: term mark

Site in curriculum: Semester 6

Subject prerequisite(s): Pharmaceutical Chemistry 1. lecture (GYTKKAM231), Pharmaceutical Chemistry 1. practice (GYTKKAM232)

Head of subject: Prof. Dr. Zsolt Szakonyi

Instructors involved in subject teaching: -

Aim of the subject:
The education of pharmaceutical chemistry aims to provide knowledge on the structure of pharmaceuticals, their structure-activity relationships, physical-chemical properties and synthesis as well as on the quality requirements of their applications, the proper chemical, physical-chemical and analytical methods for their quality control. Lectures and practicals emphasises on the improvement of chemical way of thinking and on providing a good approach in pharmacy and pharmaceutical chemistry. Furthermore, the lessons aim to raise a need of self-education in students. On the ground of these capabilities, students will be able to understand the chemical information on medicaments and to solve problems skillfully in their future carrier.

Prescribed outside practice: no

The main topics of the lectures:
Pharmacopoeia, inorganic part,
Introduction
A short history of the pharmaceutical chemistry, Process of drug development, Basic chemical processes of drug action, Receptors, Agonism-antagonism, Chemical processes of drug metabolism, Stereochemical basis of drug action
Drugs acting on the central nervous system
General anaesthetics, Sedative-hypnotics, hypnotics, drugs used in the treatment of chronic alcoholism, Anticonvulsant drugs, Narcotic analgesics and their antagonists, Neuroleptics, Anxiolytics, Antidepressants, Psychomotor stimulants and anoretics, Hallucinogens and illegal drugs, Antiparkinson agents, centrally acting antispastic agents, neuromuscular blocking agents; Nootropics, analeptics
Cholinergic and adrenergic drugs
Parasympathomimetics, cholinesterase reactivators Parasympatholytics Sympatho-mimetics, Sympatholytics
Drugs acting on periferial nervous system and on muscules
Local anesthetic agents, Spasmolytics, Neuromuscular blocking agents
Drugs acting on cardiovascular system:
Antihypertensive agents, Antianginal agents and vasodilators, agents improving cerebral circulation, Calcium channel blockers, Digitalis and other cardiac glycosides, Antiarrhythmic drugs, Antihyperlipidaemic agents
Drugs acting on metabolism:
Antitussiv agents, mucolytics, Drugs affecting gastrointestinal function, Thyroid and antithyroid drugs, agents affecting calcification, Mono- and disaccharides, insulin, synthetic hypoglycemic agents, artificial sweeteners, Sex hormones and analogues, nonsteroidal agents acting on sexual activity, Anticoagulants and haemostatics, Vitamins, Diuretics
Antiinflammatory agents
Nonsteroidal antiinflammatory agents, analgesics and antipyretics, Prostaglandins; Antiinflammatory steroids, Antiallergic antihistamins
Drugs acting on microorganisms, antineoplastic agents, drugs used for immunomodulation
Antimalarial agents, Drugs used in the chemtoherapy of helminthiasis, Antifungal agents, Sulfonamides, Antituberculotics, Nitrocompounds, quinolone derivatives, dyes, etc., Antiseptics and desinfectants, preservatives, Antibiotics, Antineoplastic agents, Antiviral agents, Drugs used for immunomodulation
New trends in drug development

Note:
Dr. Gábor Bernáth: Pharmaceutical Chemistry I
Dr. Gábor Bernáth: Pharmaceutical Chemistry II
Dr. Lajos Simon: Pharmaceutical Chemistry (Introductory and Inorganic Part)

Valuation during the semester:
The knowledge of the students is checked by tests in the semester