Team 4
Team leader: Prof. Dr. Piroska Szabó-Révész
revesz@pharm.u-szeged.hu
Research topic: Particle engineering. Nanotechnology-Nanomedicine.
Nanosized drug delivery systems, Drug delivery across artificial and biological barriers
· Particle engineering
- different preparation methods for particle size reduction (top down, bottom-up)
- micronization, nanonization and amorphization of drug crystals
- physico-chemical and chemical studies of crystalline, semi-crystalline and amorphous materials ((XRPD, NIRS, DSC, TG-MS, FT-IR, RAMAN)
- quantitative analysis of crystallinity degree (XRPD, NIRS, DSC)
· Nanotechnology-Nanomedicine
- development of nanocrystals and amorf-nanoparticles to improve the drug solubility
- development of nanosized drug delivery systems (nano-DDSs) for target therapy (liposomes, niosomes, nanocomposites, etc.)
Drug delivery across artificial and biological barriers:
- in vitro, ex vivo and in vivo permeability studies
- studies of different systems/dosage forms with micro- and nanoparticles (liquid, semi-solid, solid)
- use of alternative administration routs (intranasal and pulmonary) to reach the blood circulation